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Table 2 Characteristic of T cells infiltrating into the injured brain in acute and chronic phases after

From: The immune response of T cells and therapeutic targets related to regulating the levels of T helper cells after ischaemic stroke

Author Animal model Acute phase (within 7 days) Chronic phase (after 14 days) Year
Stubbe et al. [7] 30 min MCAO CD4+ T cells and Tregs elevating in the peri-infarct and infarct area with MHCII+ DCs and MHCII+ macrophages after ischemic stroke More CD4+ and Tregs elevating in the ischemic hemisphere consistent with increasing MHCII+ microglia, DCs and macrophages in the injured brain after ischemic stroke 2013
Vindegaard et al. [89] pMCAO Only a few CD3+ T cells infiltrating into the brain, predominantly located to the meningeal areas or in close proximity to a vessel, in the vicinity of the infarct with a few macrophage/microglia infiltrating the infarct area A high number of macrophage/microglia infiltrating the infarct area and increasing T cell numbers within the infarct core and the corpus callosum 2017
Xie et al. [90] 90 min MCAO Activated/memory phenotype of T cells (either CD4+ or CD8+) infiltrating the ischemic hemisphere Greater proportion of activated/memory T cells than the acute phase with CD25, a T cell activation antigen, increasing in both brain-invading CD4+ and CD4 T cells 2018