Fig. 8From: Protein disulfide isomerase-mediated S-nitrosylation facilitates surface expression of P2X7 receptor following status epilepticusScheme of the role of PDI-mediated S-nitrosylation of P2X7R in its trafficking to the cell membrane. SE elevates NO synthesis, which S-nitrosylates PDI. SNO-PDI transfers NO to the reduced (immature) P2X7R. In turn, SNO-P2X7R is oxidized by denitrosylases (presumably Trx-1 [8]), which facilitates its trafficking to the cell surfaceBack to article page