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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: miR-142 downregulation alleviates rat PTSD-like behaviors, reduces the level of inflammatory cytokine expression and apoptosis in hippocampus, and upregulates the expression of fragile X mental retardation protein

Fig. 1

The antisense miR-142-5p alleviates the PTSD-like behavior in rats exposed to the SPS procedure. a The procedure and timeline of PTSD experiments. b RT-qPCR detection of relative expression of miR-142 in rat hippocampus at different time points. c The relative expression miR-142 in rat hippocampus tested by RT-qPCR two weeks after LV-anti-miR-142 administration. d The immobility time in FST. e Open arm time and f open arm entries in the EPM test. g Representative tracts on day 5 during navigation trials, h the mean escape latency during the five training days, and i the percentage of time spent in the target quadrant in the MWM test. j Total distance, k distance in the central area, and l the percentage of time spent in the center of rats in the OF test. n = 6 rats per genotype. Bar graphs represent the mean ± SEM of independent experimental triplicates. One-way or two-way ANOVA followed by Bonferroni’s post hoc test; *P < 0.05, **P < 0.01

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Journal of Neuroinflammation

ISSN: 1742-2094