Skip to main content
Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: miR-142 downregulation alleviates rat PTSD-like behaviors, reduces the level of inflammatory cytokine expression and apoptosis in hippocampus, and upregulates the expression of fragile X mental retardation protein

Fig. 5

The effect of anti-miR-142 on pre-inflammatory chemokines and anti-inflammatory chemokines in PTSD rats. a Representative image indicating IL-1β (red) and β-tubulin III (green) positive cells in rat hippocampus of the control, PTSD, and Sh-miR groups. b IL-1β level in the control, PTSD, Sh-miR-NC, and Sh-miR groups tested by ELISA. c Representative image indicating TNF-α (red) and β-tubulin III (green) positive cells in rat hippocampus of the control, PTSD, and Sh-miR groups. d IL-6 level in rat hippocampus of the control, PTSD, Sh-miR-NC, and Sh-miR groups tested by ELISA. e The expression of IL-1β, IL-6, TNF-α, and IL-10 by western blot analysis in rat hippocampus of the control, PTSD, Sh-miR-NC, and Sh-miR groups. Sample western blots for all aimed protein were presented with β-actin as a loading control. f The relative level of inflammatory chemokines in each group. g Representative image indicating IL-10 (red) and β-tubulin III (green) positive cells in hippocampi of rats in control, PTSD, and Sh-miR groups. h IL-10 level in rat hippocampus of the control, PTSD, Sh-miR-NC, and Sh-miR groups tested by ELISA. n = 6 rats per genotype. Bar graphs represent the mean ± SEM of independent experimental triplicates. One-way ANOVA followed by Bonferroni’s post hoc test; *P < 0.05, **P < 0.01, ***P < 0.001

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094