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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson’s disease model

Fig. 3

Rotenone-induced microglial activation precedes neurodegeneration in mice. a The representative images of Iba-1 immunostaining were shown. b, c Quantitative analysis of Iba-1 immunostaining density. n = 5–6. d Experimental design. Mice were administered with 1.5 mg/kg rotenone. After 1, 2, and 3 weeks of initial exposure, Iba-1, Neu-N, and PSD95 were immunostained in the hippocampus and cortex. e The representative images of Iba-1, Neu-N, and PSD95 immunostaining were shown. e, f Quantitative analysis of the densities of Iba-1 and PSD95 immunostaining and the number of Neu-N+ cells in mice. n = 4. *p < 0.05, **p < 0.01; Scale bar = 50 μm

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