Fig. 4

PLX3397 and minocycline attenuate rotenone-induced cognitive deficits in mice. a Experimental design. Mice were preadministered with PLX3397 daily. Seven days later, mice received PLX3397 1 h after the rotenone injection every other day until the end of the experiment. Minocycline was administered (i.p.) to mice 2 days before rotenone and continued for consecutive 3 weeks. Morris water maze (MWM) tests were performed and followed by novel objective recognition (NOR) and passive avoidance tests (PAT) in rotenone-treated mice with or without PLX3397 and minocycline. a Escape latency, b distance traveled, c swimming speed, d first platform crossing latency, e number of platform crossings, and f time percentage in target quadrant were recorded. g–i Novel objective recognition and passive avoidance test were performed in rotenone-treated mice with or without PLX3397 and minocycline. g Recognition index, h step-through latency, and i error times in step-through were recorded. n = 11–12. *p < 0.05, **p < 0.01