Fig. 1

Effects of endometriosis on the pathologic, behavioral response, and HMGB1. a The time course of mechanical threshold at the graft site indicated EM-induced mechanical allodynia. n = 7, two-way ANOVA following Bonferroni’s post hoc test, ^*p < 0.05, EM vs sham group; ^#p < 0.05, EM vs naive group. b Representative dissection of transplant revealed cystic lesions with an amber fluid at postoperative day 7, and a rufous fluid at postoperative day 14. The red circle indicated the transplanted uterine. Scale bar 1 cm. c Representative HE staining at the lesion revealed stromal component contained fine capillary network filled with blood cells at postoperative day 14. Black arrows: congestion; red arrows: invasive immune cell; asterisk: fibroblastic proliferation. Scale bar 100 μm. d The representative protein bands of HMGB1 protein from control uterine and transplanted uterine on POD14 of EM model. n = 4, Student’s t test, ^*p < 0.05