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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis

Fig. 2

Endometriosis upregulated HMGB1 in the DRG and SDH. ac Compared with the sham group, endometriosis upregulated cytoplasmic HMGB1 in sensory neurons in the dorsal root ganglion on POD7 and POD14 after surgery. Scale bar 50 μm. df On POD14 after endometriosis, double immunostaining showed colocalization of HMGB1 with nociceptor markers including CGRP, IB4, and TRPV1, respectively. Scale bar 50 μm. g, h Compared with the sham group, endometriosis upregulated HMGB1 in spinal dorsal horn on POD14 after surgery. Scale bar 50 μm. ik On POD14 after endometriosis, immunofluorescence staining showed colocalization of HMGB1 with astrocytic marker GFAP, microglial marker IBA1 and neuronal marker NeuN. Scale bar 50 μm

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