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Fig. 11 | Journal of Neuroinflammation

Fig. 11

From: Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits

Fig. 11

DSS administration results in a sustained extraintestinal and systemic immune response. Representative images of spleens collected at the end of the fourth week of the DSS recovery phase (cohort 3). , Acute DSS administration resulted in a significant increase in spleen weights in all mice beginning during the DSS injury phase (cohort 1), b that persisted through the end of the first (cohort 2, c) and fourth weeks (cohort 3), a, d of the DSS recovery phase. Representative images of mesenteric lymph nodes (mLNs) collected at the end of the fourth week of the DSS recovery phase (cohort 3). , e. A significant increase in mLN weight was found at the end of the fourth recovery week in all DSS groups (cohort 3), f. Sham+DSS and TBI + DSS mice also exhibited increased thymus weight at the end of the fourth DSS recovery week compared to Sham and TBI mice, respectively (cohort 3), g. Data expressed as mean ± s.e.m (n = 4–7/group cohort 1 spleens; n = 14–17/group cohort 2 spleens; n = 15–21/group cohort 3 spleens; n = 6–12/group mLNs, thymus). a–f + p < 0.05 vs TBI, ++ p < 0.01 vs Sham, +++ p < 0.001 vs Naïve, ++++ p < 0.0001 vs Naïve, Sham, or TBI. g ^ p < 0.05 vs Naïve+DSS, ^^^ vs Naïve+DSS; ++ p < 0.01 vs TBI, +++ p < 0.001 vs Sham

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