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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits

Fig. 2

Prior TBI does not increase DSS disease severity or delay recovery. Prior craniotomy or TBI did not exacerbate the amount, or rate, of body weight lost upon DSS administration or regained during recovery a. Prior TBI or craniotomy did not increase disease activity index (DAI) scores at the end of the DSS injury phase (PTD35) in Sham+DSS and TBI + DSS mice compared to Naïve+DSS mice. DAI scores for DSS-treated mice returned to baseline values by the end of the third DSS recovery week (PTD 56) in a similar manner and rate, regardless of prior injury b. Data expressed as mean ± s.e.m (cohort 3, n = 15–21/group). a + p < 0.05 to p < 0.0001, ++ p < 0.01 to p < 0.0001, +++ p < 0.001 to p < 0.0001 vs water-treated counterparts; for specific p values see Supplemental Table 1. b ^^^^ p < 0.0001 Naïve vs Naïve+DSS, Sham vs Sham+DSS, TBI vs TBI + DSS, ^^^ p < 0.001 Naïve vs Naïve+DSS, Sham vs Sham+DSS

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