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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits

Fig. 9

Microglial morphology is altered by intestinal inflammation during chronic TBI. Representative images of Iba1+ microglia displaying ramified, hypertrophic, and bushy morphologies a. TBI significantly increased the number of total b, hypertrophic d, and bushy e of Iba1+ microglia in the ipsilateral hippocampus compared to Naïve and Sham mice. DSS administration resulted in a further increase in bushy Iba1+ microglia e, while decreasing the number of ramified Iba1+ microglia c in the ipsilateral hippocampus of TBI + DSS mice compared to TBI mice. Increased hypertrophic d and bushy e and decreased ramified c Iba1+ microglia were observed in the ipsilateral hippocampus of Sham+DSS mice compared to Sham mice. Data expressed as mean ± s.e.m (cohort 2, n = 7–10/group). b, c * p < 0.5 vs Sham, ** p < 0.01 vs Naïve, **** p < 0.0001 vs Naïve/Sham, ## p < 0.01 vs Sham+DSS, #### p < 0.0001 vs Sham+DSS, ^ p = <0.05 vs Naïve+DSS, ^^ p < 0.01 vs Naïve+DSS, ^^^^ p < 0.0001 vs Naïve+DSS, + p < vs Sham or TBI, ++ p < 0.01 vs Sham

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Journal of Neuroinflammation

ISSN: 1742-2094