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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: MicroRNA-210 downregulates TET2 and contributes to inflammatory response in neonatal hypoxic-ischemic brain injury

Fig. 6

TET2 knockdown exacerbated neonatal HI brain injury. Either TET2 siRNA (100 pmol; si. Tet2) or scramble (si. Ctrl) was administered into the right hemisphere of both male and female mouse brain via i.c.v. injection, neonatal HI was induced 48 h after si.Tet2 injection, and a brain infarct size was measured by TTC staining 48 h after HI. Data are expressed as mean ± SEM. n = 10 pups/group in si. Ctrl; n = 7–10 pups/group in si. Tet2. Two-tailed Student’s t test. b foot-fault test and c wire hanging test were performed 2 weeks after neonatal HI. Data are expressed as mean ± SEM. n = 6–9 pups/group in normal; n = 7–11 pups/group in si. Ctrl; n = 9–11 pups/group in si. Tet2. *p < 0.05 vs si. Ctrl. #p < 0.05 vs normal

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