Fig. 5
From: Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice
Minocycline treatment alleviates PTSD-like phenotype by suppressing microglial activation. a Microglial morphology in the HP changes upon minocycline treatment. b Microglia-derived inflammatory gene expression in HP after minocycline treatment, *p < 0.05 (Student’s t test). c–d Effect of minocycline on PTSD mice in fear freezing test. f–i Effect of minocycline on PTSD mice in open-field test. j–m Effect of minocycline on PTSD mice in EPM test; n = 12, data are expressed as means ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001 (Student’s t test). (Mino minocycline, NS no significant)