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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: White matter inflammation and cognitive function in a co-morbid metabolic syndrome and prodromal Alzheimer’s disease rat model

Fig. 8

Synaptic density in the hippocampus identified by synaptophysin (SYN) immunohistochemistry. a 20× photomicrographs of the pyramidal neurons in the dorsal hippocampus CA1 (top row) and CA3 (bottom row) subregions. Scale bar 50 μm. Boxed area corresponds to a field defined for quantification. b Synaptophysin area coverage (%) in CA1 and CA3 regions of the hippocampus. Animal numbers are n = 6 in each group. Values are presented as mean ± SEM. Significance is indicated by * for HCD WT vs both TG groups in CA1 and for both TG groups vs both WT groups in CA3 region. HCD hypercaloric diet, TG transgenic, WT wildtype. One-way ANOVA, Tukey’s multiple comparisons test, p < 0.05

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Journal of Neuroinflammation

ISSN: 1742-2094