White matter inflammation and cognitive function in a co-morbid metabolic syndrome and prodromal Alzheimer’s disease rat model

Table 1 Serum glucose-, insulin-, and lipid-related measures

	Control WT	Control TG	HCD WT	HCD TG
Glucose, mmol/l (initial)	3.73 ± 0.10	3.82 ± 0.07
Glucose, mmol/l (post)	3.6 ± 0.13	3.63 ± 0.14	3.96 ± 0.13	3.91 ± 0.12
AUC IGTT (initial)	929.98 ± 45.91	786.08 ± 53.51
AUC IGTT (post)	891.08 ± 82.09	907.25 ± 79.11	1568.85 ± 172.74^*†	892.44 ± 90.58
Insulin, pmol/ml (post)	243.1 ± 28.60	237.9 ± 29.16
HOMA-IR (post)	0.19 ± 0.03	0.17 ± 0.03	0.56 ± 0.09^*	0.58 ± 0.13^*
Chol:HDL, mmol/l	1.64 ± 0.09	1.49 ± 0.06	2.43 ± 0.17^*	2.44 ± 0.17^*

Initial—data obtained prior to the diet assignment; rats used in the study were combined by genotype. Post—data collected after 11–12 weeks on the diets. Non-specified—data obtained at the end of the study. All measures (except AUC IGTT) represent fasting state values. Values are presented as mean SEM. The symbols * and † indicate significance for HCD group vs. both control groups and between HCD groups respectively. One-way ANOVA, Tukey’s multiple comparison test; p < 0.05. AUC area-under-the-curve, Chol total cholesterol, HCD hypercaloric diet, HDL high-density lipoprotein cholesterol, HOMA-IR homeostasis model assessment index, IGTT intraperitoneal glucose tolerance test, TG transgenic, WT wildtype

ISSN: 1742-2094