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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Cyclophilin a signaling induces pericyte-associated blood-brain barrier disruption after subarachnoid hemorrhage

Fig. 4

Effects of exogenous CypA and CypA small interfering RNA pretreatment on MMP9 secretion and activities after subarachnoid hemorrhage. a Representative western blot bands of MMP9 P-p65and total P=p65from ipsilateral hemisphere after SAH. Quantitative analyses of b MMP9, c Pp65, and d total p-65 expressions from ipsilateral hemisphere after SAH. e Representative zymography bands and f quantitative analysis of MMP9 activities from ipsilateral hemisphere after SAH. g Representative bands and quantitative analysis of (H) ZO-1, i Collagen IV, j Occludin, and k Claudin 5 expressions in ipsilateral hemisphere of brain specimen at 24 h after SAH. Relative densities of each protein have been normalized against the sham group. n = 6. @: vs. sham P < 0.05, #: vs. SAH + vehicle P < 0.05, and $: vs. SAH + scrambled siRNA P < 0.05

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