Fig. 7
CD147 inhibition reduced MMP9 secretion without effecting CypA endocytosis. a Representative FITC-positive cell percentage after treatment of CD147 siRNA and CypA-FITC on cultured pericyte. n = 6. @: vs. DMSO P < 0.05. b ELISA results of MMP9 concentrations in pericyte culture media after exogenous CypA, CD147 siRNA, and chlorpromazine (CPZ) treatment. n = 6. @: vs. Hb P < 0.05. #: vs. Hb + CypA P < 0.05, &: vs. Hb + CypA + Scr siRNA P < 0.05. $: vs. Hb + CypA + vehicle P < 0.05. c Representative zymography bands and quantitative analysis of MMP9 of cultured pericyte supernatant after exogenous CypA, CD147 siRNA, and CPZ treatment. Relative densities of each group have been normalized against the first group. n = 6. #: vs. Hb + vehicle P < 0.05. $: vs. Hb + CypA P < 0.05, *: vs. Hb + Scr siRNA P < 0.05, @: vs. Hb + CypA siRNA P < 0.05