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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Pre-treatment with the viral Toll-like receptor 3 agonist poly(I:C) modulates innate immunity and protects neutropenic mice infected intracerebrally with Escherichia coli

Fig. 5

Brain IFN-γ levels and NK cell numbers 30 h after E. coli infection in neutropenic mice after poly(I:C) pre-conditioning. a IFN-γ levels were higher in poly(I:C)-treated than in control animals (P = 0.0007). b Poly(I:C) pre-treated infected animals exhibited higher absolute numbers of NK cells in the brain compared with the vehicle group (P = 0.009). c The percentage of NK cells among the total amount of CD45+ leukocytes was significantly increased in the brain of poly(I:C)-primed animals compared with the vehicle group (P = 0.017). Each symbol represents an individual mouse. Horizontal bars indicate median values. Statistical analysis was performed by the Mann-Whitney U test

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Journal of Neuroinflammation

ISSN: 1742-2094