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Table 1 Expressions of COX-1 and COX-2 in dorsal root ganglia (DRG) and spinal cord

From: Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception

DRG and/or spinal cord

COX isoforms

Animal models

Expression

References

lumbar spinal cord

COX-2 mRNA

Freund’s adjuvant-induced rat

Increase

[7]

gray matter of the spinal cord

COX-1 protein

Normal rat

Detection

[14]

superficial dorsal horn of the spinal cord (laminae I and II) Around the central canal (lamina X)

COX-2 protein

Normal rat

Detection

[14]

small to medium sized (<  1000 μm2) DRG

COX-1 protein

Normal rat

Detection

[14, 16]

DRG

COX-2 protein

Normal rat

No detection

[14, 16]

spinal cord

COX-1, COX-2 protein

Kaolin and carrageenan-induced arthritis rat

No change in COX-1, increase in COX-2

[8]

spinal cord

COX-1 mRNA

COX-2-deficient mice

Increase

[15]

spinal cord

COX-2 mRNA

COX-1-deficient mice

No change

[15]

part of COX-1-positive DRG neurons

COX-1 protein

Freund’s adjuvant-injected rat

No change

[16]

DRG

COX-2 protein

Freund’s adjuvant-injected rat

No detection

[16]

spinal cord

COX-2 protein

Freund’s adjuvant-injected rat

Increase

[6]

L4 and L5 DRG

COX-1 protein

COX-1/COX-2-deficient mice

No detection in COX-1

[17]

L4 and L5 DRG

COX-2 protein

COX-1/COX-2-deficient mice

No detection

[17]

L4 and L5 DRG

COX-1, COX-2 protein

Normal mouse

No detection in COX-2

[17]

L4 – L6 DRG and spinal cord,

COX-1, COX-2 protein

Normal rat

Detection

[10]

spinal cord

COX-2 mRNA / protein

Formalin-induced inflamed rat

Increase in mRNA, no change in protein

[9]

L4 and L5 DRG

COX-1 mRNA

Collagen-induced arthritis mouse

No change

[17]

L4 and L5 DRG

COX-2 mRNA

Collagen-induced arthritis mouse

No detection

[17]

spinal cord

COX-1 mRNA / Protein

LPS-induced inflamed mouse

No change

[13]

spinal cord

COX-2 mRNA / Protein

LPS-induced inflamed mouse

Increase

[13]

spinal cord

COX-2 mRNA / protein

LPS-induced inflamed mouse

increase

[18]

DRG and spinal cord

COX-1, COX-2 mRNA

Carrageenen-induced inflamed mouse

No change in COX-1, Increaser in COX-2

[19]

L4 DRG

COX-2 mRNA / protein

Freund’s adjuvant-injected rat

Increase

[20]

TRPV1-positive cells in L5 DRG

COX-1, COX-2 protein

IL-1β- or carrageenan-induced rat

Increase

[21]