DRG and/or spinal cord | COX isoforms | Animal models | Expression | References |
---|---|---|---|---|
lumbar spinal cord | COX-2 mRNA | Freund’s adjuvant-induced rat | Increase | [7] |
gray matter of the spinal cord | COX-1 protein | Normal rat | Detection | [14] |
superficial dorsal horn of the spinal cord (laminae I and II) Around the central canal (lamina X) | COX-2 protein | Normal rat | Detection | [14] |
small to medium sized (<  1000 μm2) DRG | COX-1 protein | Normal rat | Detection | |
DRG | COX-2 protein | Normal rat | No detection | |
spinal cord | COX-1, COX-2 protein | Kaolin and carrageenan-induced arthritis rat | No change in COX-1, increase in COX-2 | [8] |
spinal cord | COX-1 mRNA | COX-2-deficient mice | Increase | [15] |
spinal cord | COX-2 mRNA | COX-1-deficient mice | No change | [15] |
part of COX-1-positive DRG neurons | COX-1 protein | Freund’s adjuvant-injected rat | No change | [16] |
DRG | COX-2 protein | Freund’s adjuvant-injected rat | No detection | [16] |
spinal cord | COX-2 protein | Freund’s adjuvant-injected rat | Increase | [6] |
L4 and L5 DRG | COX-1 protein | COX-1/COX-2-deficient mice | No detection in COX-1 | [17] |
L4 and L5 DRG | COX-2 protein | COX-1/COX-2-deficient mice | No detection | [17] |
L4 and L5 DRG | COX-1, COX-2 protein | Normal mouse | No detection in COX-2 | [17] |
L4 – L6 DRG and spinal cord, | COX-1, COX-2 protein | Normal rat | Detection | [10] |
spinal cord | COX-2 mRNA / protein | Formalin-induced inflamed rat | Increase in mRNA, no change in protein | [9] |
L4 and L5 DRG | COX-1 mRNA | Collagen-induced arthritis mouse | No change | [17] |
L4 and L5 DRG | COX-2 mRNA | Collagen-induced arthritis mouse | No detection | [17] |
spinal cord | COX-1 mRNA / Protein | LPS-induced inflamed mouse | No change | [13] |
spinal cord | COX-2 mRNA / Protein | LPS-induced inflamed mouse | Increase | [13] |
spinal cord | COX-2 mRNA / protein | LPS-induced inflamed mouse | increase | [18] |
DRG and spinal cord | COX-1, COX-2 mRNA | Carrageenen-induced inflamed mouse | No change in COX-1, Increaser in COX-2 | [19] |
L4 DRG | COX-2 mRNA / protein | Freund’s adjuvant-injected rat | Increase | [20] |
TRPV1-positive cells in L5 DRG | COX-1, COX-2 protein | IL-1β- or carrageenan-induced rat | Increase | [21] |