Table 3 Functional effects of peripherally injected 15d-PGJ2 on nociceptive responses

Normal mouse

Intraplantar

32 nmol/25 μl

↑Licking, flinching

Disappeared in TRPA1^−/−

[223]

Normal mouse

Intraplantar

15 nmol/20 μl

↑Licking, lifting

Disappeared in TRPA1^−/−

[224]

Normal mouse

Intraplantar

15 nmol/10 μl

↑Licking, lifting

Disappeared in TRPA1^−/−

[225]

Complete Freund’s adjuvant injected mouse

Intraplantar

1.5 or 15 mM/10 μl

↓ Mechanical hypersensitivity

Disappeared in TRPA1^−/−

[226]

Sciatic nerve-injured rat

Intrathecal

50–200 μg/15 μl

↓ Mechanical and cold hypersensitivity

Attenuated by PPARγ antagonist

[227]

Sciatic nerve-injured rat

Intraperitoneal Iintracerebroventricular

100 μg

↔ Mechanical and cold hypersensitivity

[227]

Carrageenan-induced inflamed rat

Intraplantar

30–300 ng/100 μl

↓ Mechanical hypersensitivity

Attenuated by PPARγ antagonist

[228]

Formalin-induced TMJ rat

Into temporomandibular joint

100 ng/50 μl

↓ Mechanical hypersensitivity

Attenuated by PPARγ antagonist

[228]

Formalin-induced inflamed rat

Intraplantar

100 ng/50 μl

↔ Mechanical and cold hypersensitivity

[228]

PGE₂-induced inflamed rat

Intraplantar

30–300 ng/50 μl

↓ Mechanical hypersensitivity

Attenuated by PPAR, Opioid receptor, Nitric oxide/cGMP/PKG)/K⁺_ATP pathway antagonists

[228]

PGE₂-induced inflamed rat

Intraganglionic

100 ng/10 μl

↔ Mechanical and cold hypersensitivity

[228]

TNFα induced inflamed rat

Intraplantar

100 ng/100 μl

↓ Mechanical hypersensitivity

[228]

Formalin-induced TMJ rat

Into temporomandibular joint

1–100 ng/50 μl

↓ Mechanical hypersensitivity

Attenuated by PPARγ antagonist, Opioid receptor, (Nitric oxide/cGMP/PKG)/K⁺_ATP pathway antagonists

[229]