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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis

Fig. 5

Immunofluorescence staining assay of astrocytes and microglia in the SDH. a Immunofluorescence staining of OX-42 (green), b Immunofluorescence staining of GFAP (green). Scale bar = 100 μm. When compared with the control group, OX-42 and GFAP staining were significantly increased in the SDH of CYP group; moreover, activated astrocytes and microglia presented hypertrophied cell bodies and significantly increased dendrites. c, d ANA-12 treatment restrained activation of astrocytes and microglia induced by CYP. The BDNF injection further promoted activation of astrocytes and microglia induced by CYP. All data were calculated as mean ± SEM (n = 5 per group). ***p < 0.001 vs. the control group, $$$p < 0.001 vs. the CYP + rBDNF group, ###p < 0.001 vs. the CYP + ANA-12 group

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