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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Amyloid beta and diabetic pathology cooperatively stimulate cytokine expression in an Alzheimer’s mouse model

Fig. 2

APP/PS1 and db/db pathologies cooperatively promote cytokine expression. a Luminex analysis of 22 cytokines (columns, z-scored) expressed in the cortex of APP/PS1, db/db, and APP/PS1xdb/db mice (each row is a cortex sample). b PLSDA identified two profiles of cytokines, LV1 and LV2, that distinguished groups. LV1 separated APP/PS1xdb/db mice (positive) from both APP/PS1 and db/db mice (negative). LV2 separated STZ mice (positive) from APP/PS1 mice (negative). c The weighted profile of cytokines representing LV1. Errors bars on each cytokine were computed by PLSDA model regeneration using iterative subsampling of 80% of samples (mean ± SD). d Scoring the data for each sample in b on LV1 revealed that combined APP/PS1xdb/db pathology cooperatively increased the LV1 cytokine profile compared to either APP/PS1 or db/db pathology alone (**p < 0.01, Welch’s ANOVA with Dunnett’s T3 test). e The weighted profile of cytokines representing LV2. Errors bars on each cytokine were computed by PLSDA model regeneration using iterative subsampling of 80% of samples (mean ± SD). f Scoring the data for each sample in b on LV2 revealed that APP/PS1xdb/db is significantly upregulated on the LV2 cytokine profile compared to db/db (*p < 0.05, Welch’s ANOVA with Dunnett’s T3 test). Data were collected from 21 animals (14 M/14F, APP/PS1 2 M/51F, db/db 3 M/5F, APP/PS1xdb/db 6 M/1F)

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