Fig. 4

Plasma amyloid levels correlated with distinct signatures of brain cytokine expression in APP/PS1 or APP/PS1xdb/db mice. a Plasma Aβ1-42 levels were significantly decreased in APP/PS1xdb/db compared to APP/PS1 mice (mean ± SEM; *p < 0.05, Student’s t test). b Distinct profiles of cytokines correlated with Aβ1-42 levels in db/db or APP/PS1xdb/db mice (mean ± SD in an iterative subsampling of 80% of samples). c Plasma Aβ1-42 levels were decreased in APP/PS1xdb/db compared to APP/PS1 mice and significantly correlated with brain composite cytokine score on LV1. d Plasma Aβ1-40 levels trend towards a decrease in APP/PS1xdb/db compared to APP/PS1 mice (mean ± SEM; p = 0.085, Student’s t test) e Distinct profiles of cytokines correlated with Aβ1-40 levels in db/db or APP/PS1xdb/db mice, ordered with respect to b (mean ± SD in an iterative subsampling of 80% of samples). f Plasma Aβ1-40 concentration was decreased in APP/PS1xdb/db compared to controls significantly correlated with brain composite cytokine score on LV1. Data were collected from ten animals (4 M/6F, APP/PS1 1 M/4F, APP/PS1xdb/db 3 M/2F)