Fig. 7From: MicroRNA-7, synergizes with RORα, negatively controls the pathology of brain tissue inflammationRORα and miR-7 were co-expression in the neuron. WT mice and miR-7def mice (n = 6 per group) were intraperitoneally injected with LPS (2.5 mg/kg of body weight) and control group with PBS, respectively. After 12 h, a–c the colocated expression of RORα and NeuN, GFAP or IBA-1 were detected by double immunofluorescence labeling assay. d The expression of pre-miR-7-2 in neuron was analyzed by IF and FISH assay (n = 6 per group). e–h The change of neuron and Nissl bodies were detected by IHC and Nissl staining, respectively (n = 3, one-way ANOVA, **P < 0.01)Back to article page