Fig. 10From: Paroxetine suppresses reactive microglia-mediated but not lipopolysaccharide-induced inflammatory responses in primary astrocytesEffect of paroxetine on neurotrophic responses of astrocytes. Cells were pretreated with paroxetine at different concentrations for 30 min followed by incubation with microglia conditioned media for 24 h. a Quantitative PCR analyses of BDNF and MANF expression. The mRNA levels were expressed relative to the one incubated with M/Lps alone, which was set as 100. b Concentrations of BDNF in culture media. Values are means ± SE, n = 3 for a, n = 4 for b. Statistical comparisons were performed using one-way ANOVA, followed by Tukey’s post hoc test. Different letters indicate p < 0.05. BDNF, brain-derived neurotrophic factor; MANF, mesencephalic astrocyte-derived neurotrophic factor; M/C, microglia conditioned medium without LPS stimulation; M/Lps, microglia conditioned medium pre-activated with LPSBack to article page