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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense

Fig. 8

G1 enhancement of spatial learning and memory after GCI are abolished by G36 treatment or IL1RA knockdown. a Barnes maze was performed to examine spatial learning and memory. a The time (s) spent finding target hole (TH) at days 7, 8, and 9 after ischemia insult. b Exploration time spent in the target quadrant (TQ) that initially contained the TH at day 10 following reperfusion. c Moving speed of the rats in the probe trail on the fourth day of the test. d, e Representative traces indicating the sample paths of the rats from the maze latency trials and probe trials. Data are expressed as mean ± SE from 5 different animals. P < 0.05 considered as statistic difference between the groups. 1 sham, 2 IR, 3 G1 + G36, 4 G1, 5 G1 + IL1RA-AS

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Journal of Neuroinflammation

ISSN: 1742-2094