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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense

Fig. 9

G1 enhancement of reference memory after GCI is abolished by G36 treatment or IL1RA knockdown. The novel object recognition (NOR) test was performed following GCI. Five-minute NOR tests at 13 and 14 days after 12-min ischemia were performed to monitor the long-term memory (a). b Time spent exploring the two familiar objectives on the training day. c The time spent exploring each object (familiar object and novel object) and d the discrimination index percentage (the time spent exploring novel object divided by total time spent). e Representative traces of the indicated groups on the testing day. All the data are expressed as means standard error from 6 to 7 animals in each group. *P < 0.05 considered as a statistic difference between the groups. n.s., no significant change; Ob, object; Fa-ob, familiar object; Nov-ob, novel object

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Journal of Neuroinflammation

ISSN: 1742-2094