Fig. 2

Cytokines contributing to the three immune networks identified through constrained principle component analysis (CPCA). Network membership was defined based on component loadings from the CPCA. Activated cytokines are indicated in dark blue, and inhibited cytokines indicated in light blue, with color gradation depicting the value of the component loading. For each network, the strength (|r|) and the significance (p value) of the correlation between groups (C/TD, C/ND, A/TD, A/ND) and component scores are indicated. The cytokine networks indicated in white were not significantly correlated with the group, as indicated in the figure. Abbreviations: C/TD, control mother (low to no alcohol), typically developing child (n = 15); C/ND, control mother (low to no alcohol), neurodevelopmental delay in the child (n = 12); A/TD, alcohol-consuming mother, typically developing child (n = 15); A/ND, alcohol-consuming mother, neurodevelopmental delay in the child (n = 17)