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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model

Fig. 7

SR9009 application attenuated microglial activation in the pilocarpine-induced SE model. a Iba1 immunofluorescence staining in the CA1 and CA3 regions of the hippocampus in the four groups. b, c The number of microglia was drastically decreased in SR9009-treated pilocarpine mice compared with vehicle-treated pilocarpine mice. d Western blotting analysis demonstrated that SR9009 significantly reduced the protein level of Iba1 in the hippocampus after SE. n = 3 for each group. The data presented as the mean ± SD. NS, not significant, †p < 0.001. Scale bar = 50 μm

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Journal of Neuroinflammation

ISSN: 1742-2094