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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model

Fig. 8

Treatment with SR9009 decreases apoptosis and the loss of hippocampal neurons in the SE. a TUNEL-positive cells in the CA1 and CA3 regions of the hippocampus of the four groups in mice are displayed. b, c The number of TUNEL -positive cells in the CA1 and CA3 regions were calculated. Treatment with SR9009 after SE resulted in a diminished number of TUNEL-positive cells in the CA1 and CA3 regions. d, e A representative immunoblot showing protein immunoreactivity for cleaved caspase-3 (17 kDa) in the hippocampus of the four groups. A significant decrease in the cleaved-caspase3 level was observed in the SR9009-treated pilocarpine group compared to the vehicle-treated pilocarpine group. e NeuN immunofluorescence staining in the CA1, CA3, and DG regions of the hippocampus in the four groups. f, g The number of NeuN-positive cells in the SR9009-treated pilocarpine group was significantly higher than that in the vehicle-treated pilocarpine group. h SR9009 did not affect the number of NeuN-positive cells in the DG after SE. n = 3 for each group. The data presented as the mean ± SD. NS, not significant, *p < 0.05, †p < 0.001. Scale bar = 50 μm (a, e)

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Journal of Neuroinflammation

ISSN: 1742-2094