Fig. 6

Quantitative analysis of the effect of tibolone and the aromatase inhibitor letrozole on the phagocytosis of brain-derived cellular debris. Cy3 fluorescence intensity per cell in male (a) and female (b) astrocytes treated for 39 h with tibolone, tibolone and/or letrozole, or control medium. Cells were then incubated for 1 h with Cy3-conjugated brain-derived cellular debris. Data are presented as median ± ranges. Significant differences: ***p < 0.001 versus the control group of the same sex, ^$$$p < 0.001, ^$$p < 0.01, ^$p < 0.05 versus the tibolone group of the same sex, ^@@@p < 0.001 versus the letrozole group of the same sex, ^###p < 0.001, ^##p < 0.01 versus the same experimental group of the other sex, being annotated in the group with higher median