From: Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review
Publication | Study design | Country | Clinical scales | Investigation | |
---|---|---|---|---|---|
Author, year | Medium | Markers | |||
A. Immunoglobulins | |||||
Kanchanatawan et al. 2017 [40] | Observational cross-sectional with healthy controls | Thailand | DSM IV, FF, PANSS, SANS, SDS, HAM-D, HAM-A, CANTAB | Blood | 3HK, KYNA, QUIN, AA, XA, PA, and IgA and IgM responses to these six TRYCATs |
Kanchanatawan et al. 2018a [41] | Observational cross-sectional with healthy controls | Thailand | DSM-IV-TR, Thai version of MINI, SDS, SANS, PANSS, BPRS | Blood | 3HK, KA, QUIN, AA, XA, PA, and IgA and IgM responses to these six TRYCATs |
Kanchanatawan et al. 2018b [42] | Observational cross-sectional with healthy controls | Thailand | DSM-IV, SDS, SANS, PANSS, BPRS | Blood | 3HK, KYNA, QUIN, AA, XA, PA, and IgA responses to these six TRYCATs |
Bechter et al. 2010 [43] | Observational cross-sectional with healthy controls | Germany | ICD-10 | Blood and CSF | KYN, Trp, albumin, IgG, IgA, IgM, oligoclonal IgG |
B. Interleukins | |||||
Szymona et al. 2017 [44] | Observational prospective case-control study | Poland | ICD-10 (F20), SAPS, SANS, PANSS | Blood | KYNA, 3-HK, sIL-2R, IFN-α, IL-4 |
Barry et al. 2009 [45] | Observational cross-sectional with healthy controls | Ireland | DSM-IV, SCID-I for DSM-IV, SAPS, SANS, CDSS | Blood | L-Trp, KYN, 3HK, KYNA, 3-hydroxy-anthranilic acid, XA and 3-nitro-l-tyrosine |
Kim et al. 2009 [46] | Observational prospective case-control study | Korea | DSM IV, PANSS | Blood | Trp and KYN as well as IL-2, IL-4, IL-6, TNF-α, IFN-γ, TGF-β1 |
Schwieler et al. 2015 [47] | Observational cross-sectional with healthy controls | Sweden | DSMIV, BPRS, GAF | CSF | Cytokines: IL1β, IL2, IL4, IL6, IL8, IL10, IL18, TNFα, IFNα2a, and IFNγ as well as KYNA, KYN, and Trp |
Human astrocyte culture | Effects of IL-6 on KYN and KYNA | ||||
Kegel et al. 2017 [48] | Observational cross-sectional with healthy control twins | Sweden | SCID-I, SCID-II, SANS, SAPS, SPQ-B, HAM-D, YMRS, GAF | CSF | KYNA, QUIN, Trp, IL-6, IL-8, TNF-α, albumin |
Blood | CRP and albumin | ||||
C. C-reactive protein | |||||
Wurfel et al. 2017 [49] | Observational cross-sectional with healthy controls | USA | DSM-IV, HAM-D, YMRS, BPRS version 4.0, CORE assessment of psychomotor change | Blood | High-sensitivity CRP, Trp, KYN, KYNA, 3HK |