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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer’s disease

Fig. 5

Representative immunoblots and box plots showing FC levels of CHI3L1 (a), CHI3L2 (b), GFAP (c), CD44 (d), C1q (e), and NPTX2 (f) in NCI, MCI, mAD, and sAD. β-tubulin was used to normalize the immunoreactive signal obtained by densitometry. Statistical analysis revealed that CHI3L1, NPTX2, GFAP, and C1q protein levels were stable across clinical groups, whereas there was a significant decrease in CHI3L2 levels, and CD44 significantly increased in sAD compared to NCI (p = 0.001). Abbreviations: NCI, non-cognitive impairment; MCI, mild cognitive impairment; mAD, mild to moderate AD; sAD, severe AD

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