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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Bone mesenchymal stem cell-derived exosomal microRNA-29b-3p prevents hypoxic-ischemic injury in rat brain by activating the PTEN-mediated Akt signaling pathway

Fig. 4

miR-29b-3p in BMSC-derived exosomes ameliorates OGD-induced cell injury. a, b Apoptosis of cortical neurons after treated with BMSC-derived exosomes detected by TUNEL staining (scale bar = 50 μm). c, d The expression of neuronal apoptosis- and BMECs angiogenesis-related proteins analyzed by western blot analysis. e Representative images and quantification of tube formation ability of BMECs after treated with BMSC-derived exosomes (scale bar = 100 μm). *p < 0.05 vs. the NC mimic group, #p < 0.05 vs. the NC inhibitor group. The measurement data are expressed as mean ± standard deviation. The comparison between the two groups was carried out by the independent sample t test. The experiment was repeated in triplicate

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