Skip to main content
Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation

Fig. 2

Loss of CLEC14A exacerbated cerebral injury with VEGFR2 activation in MCAO stroke model. a, c Images of whole brains and comparison of Evans blue dye (EB) leakage in brains (P8 and adult) after EB injection (intraperitoneal route) in WT and CLEC14A KO mice (n = 6, each group). b, d The quantitative analysis of Evans blue (EB) dye extravasation using spectrophotometer, 24 h after intraperitoneal injection of EB dye. e TTC staining of brain slices in the sham, WT, and CLEC14A KO groups 24-h post ischemia-reperfusion. Severe infarction was present in the CLEC14A KO group. Scale bar = 1 mm. f Percentage of infarct volume in the WT and CLEC14A KO groups 24 h after ischemia-reperfusion. g Neurological scores of WT and CLEC14A KO mice were evaluated. h VEGFR2, pVEGFR2 protein expression in ipsilateral brain lysate after ischemia-reperfusion injury. i, j Quantification data of relative pVEGFR2 and VEGFR2 protein expression. n = 6 per group; *P < 0.05, **P < 0.01, ***P < 0.001. The results are mean values and the error bars represent the mean ± SD

Back to article page