Fig. 2
From: Glial remodeling enhances short-term memory performance in Wistar rats
The Cx3cr1-Dtr rat allows selective inducible ablation of microglia. Numbers of microglia were reduced throughout the hippocampus by 48 h after diphtheria toxin in Cx3cr1-Dtr rats compared to wild-types (wt) with microglia repopulating the hippocampus by 7 days (n = 5–8 per group). a, b CA1 (significant genotype by day interaction: F(2, 31) = 6.61, p = 0.004); c, d CA3 (interaction: F(2, 35) = 6.66, p = 0.004); e, f hilus (interaction: F(2, 34) = 3.53, p = 0.040); g, h subgranular/granular (significant effect of day: F(1, 35) = 10.43, p < 0.001); or i, j molecular (interaction: F(2, 34) = 6.61, p = 0.004) regions of the dentate gyrus. *p < 0.05 with Tukey post hoc tests. $ significant main effect of day (recovery time). Data are expressed as mean ± SEM. Scale bars = 10 μm