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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Glial remodeling enhances short-term memory performance in Wistar rats

Fig. 4

Microglial ablation improves short-term memory function as the microglia repopulate the brain. Memory task performance at 7 days after diphtheria toxin injection to ablate microglia in Cx3cr1-Dtr rats compared to wild-types (wt). a Y-maze latency to novel arm entry (t(20) = 2.11, p = 0.048; n = 8–11). b Y-maze discrimination ratio (one sample t test to zero: wt: t(10) = 4.39, p = 0.0013. Cx3cr1-Dtr: t(11) = 5.24, p = 0.0003). c Novel object recognition discrimination ratio (one sample t tests to zero: wt: t(11) = 13.73, p < 0.0001. Cx3cr1-Dtr: t(11) = 18.72, p < 0.0001; n = 10–12. Cx3cr1-Dtr versus wt: t(22) = 4.20, p < 0.001). d Novel place recognition discrimination ratio (one sample t test to zero: wt: t(6) = 2.25, p = 0.066. Cx3cr1-Dtr: t(6) = 4.59, p = 0.004; n = 7 per group. Cx3cr1-Dtr versus wt: t(12) = 2.54, p = 0.026). e Heat maps illustrating familiar object (square) and novel object (circle) exploration in the NOR. f Heat maps illustrating novel place (circle) exploration in the NPR. Note, in this test both objects were identical; the superimposed circle is to show the novel position. Heat maps were generated in Ethovision using the over-heatmap setting allowing comparison between the representative animals. *p < 0.05: Student’s unpaired t tests. Data are expressed as mean ± SEM

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