Fig. 8
From: Glial remodeling enhances short-term memory performance in Wistar rats
Initial changes to neuronal number and memory dissipate as microglial morphology normalizes. Microglial profiles, memory performance, and neuronal markers at 14 days after diphtheria toxin injection to ablate microglia in Cx3cr1-Dtr rats compared to wild-types (wt). a Classification of repopulated microglia morphology in the CA1 (increased ameboid; U = 0, p = 0.0012; fewer ramified; U = 1, p = 0.0012). b CA3 (fewer ameboid; U = 6, p = 0.024). c Hilus. d Subgranular/granular. e Molecular regions of the dentate gyrus. f Hippocampal astrocyte (glial fibrillary acid protein; GFAP) density. g Novel object recognition discrimination ratio (n = 11–12). h Number of DCX-positive cells in the subgranular/granular region of the dentate gyrus. i Number of NeuN-positive cells in the CA1. j CA3. k Hilus. l Subgranular/granular region of the dentate gyrus (n = 5–6). *p < 0.05; a–e: Mann-Whitney U tests. Data are expressed as mean ± SEM