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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis

Fig. 3

CXCR2+ neutrophils are not required for CNS infiltration of immune cells. Numbers of total mononuclear cells, adaptive immune cells (B cells: CD45+CD19+; CD4+T cells: CD45+CD3+CD4+; CD8+T cells: CD45+CD3+CD8+), innate immune cells (neutrophils: CD45++Ly6Ghigh; dendritic cells: CD45+ CD11c+; macrophages: CD45+CD11b+Ly6GCD11c), and CNS resident glia (microglia: CD45lowCD11b+) in the a brain and b spinal cord of control or Cxcr2 cKO mice. Numbers of total mononuclear cells, adaptive immune cells (B cells: CD19+; CD4+T cells: CD3+CD4+; CD8+T cells: CD3+CD8+), and innate immune cells (neutrophils: CD11b+Ly6Ghigh; dendritic cells: CD11c+; macrophages: CD11b+ Ly6GCD11c) in the c spleen and d lymph nodes of control or Cxcr2 cKO mice. Control EAE, n = 5; Cxcr2 cKO EAE, n = 7. *p < 0.05, two-tailed unpaired Student’s t test

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