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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Activated STAT3 signaling pathway by ligature-induced periodontitis could contribute to neuroinflammation and cognitive impairment in rats

Fig. 10

Effects of ligature-induced periodontitis on STAT3 signaling pathway. Expression of pSTAT3 in periodontal tissue (a) and cortex (b) was detected via immunohistochemistry (×100 and ×400, bar = 200 μm and 50 μm, respectively). Expression of JAK2, STAT3, and pSTAT3 (Tyr-705) was further measured by WB (ch). High expression of pSTAT3 was effectively inhibited by CTS. pSTAT3/STAT3 was upregulated by the periodontal ligature. The quantification of related protein expression: d JAK2 in periodontal tissue (F = 1.800, p = 0.2251), e pSTAT3 (Tyr-705)/STAT3 in periodontal tissue (F = 6.685, p = 0.0143), g JAK2 in cortex (F = 1.361, p = 0.3224), h pSTAT3 (Tyr-705)/STAT3 in the cortex (F = 6.169, p = 0.0178). (n = 3 per group, one-way ANOVA, *p < 0.05 compared to the control group and #p < 0.05 compared to the CP group)

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