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Fig. 11 | Journal of Neuroinflammation

Fig. 11

From: Activated STAT3 signaling pathway by ligature-induced periodontitis could contribute to neuroinflammation and cognitive impairment in rats

Fig. 11

Effects of ligature-induced periodontitis on APP processing. RT-PCR was performed to detect mRNA expression of APP, APLP1, and APLP2 on genes in comparison to the control group, while these changes were reversed by CTS. The mRNA level of APP and the homologs in the cortex in each group: a APP (n = 4, F = 1.361, p = 0.3224), b APLP1 (n = 4, F = 1.361, p = 0.3224), c APLP2 (n = 6, F = 1.361, p = 0.3224). The mRNA level of secretases in the cortex in each group: d ADAM10 (n = 4, F = 1.361, p = 0.3224), e ADAM17 (n = 4, F = 1.361, p = 0.3224), f BACE1 (n = 6, F = 1.361, p = 0.3224), g PS1 (n = 4, F = 1.361, p = 0.3224), h PS2 (n = 6, F = 1.361, p = 0.3224). (n = 4–6 per group, one-way ANOVA, *p < 0.05, **p < 0.01, and ***p < 0.001 compared to the control group and #p < 0.05, ##p < 0.01, and ###p < 0.001 compared to the CP group)

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