Journal of Neuroinflammation

Table 1 Ex vivo biodistribution (percentage of injected dose per gram of tissue) of ⁶⁸Ga-FOL at 30 min post-injection in rats with fDTH-EAE after treatment with EC2319 or saline

From: Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis

Organ	Day 14				Day 90
Organ	EC2319 (n = 8)	Saline (n = 8)	P value	Treatment effect	EC2319 (n = 10)	Saline (n = 10)	P value	Treatment effect
Adrenal glands	0.24 ± 0.04	0.25 ± 0.03	0.83	↓	0.16 ± 0.04	0.20 ± 0.05	0.05	↓
Blood	0.03 ± 0.01	0.014 ± 0.002	0.003	↑	0.06 ± 0.03	0.03 ± 0.03	0.03	↑
Brain	0.020 ± 0.004	0.011 ± 0.003	< 0.001	↑	0.02 ± 0.01	0.02 ± 0.01	0.46	↑
Heart	0.12 ± 0.02	0.19 ± 0.06	0.02	↓	0.09 ± 0.02	0.09 ± 0.02	0.95	↑
Kidneys	12.80 ± 2.02	6.71 ± 1.34	< 0.001	↑	8.21 ± 3.21	8.51 ± 1.99	0.81	↓
Liver	0.30 ± 0.05	0.47 ± 0.13	0.007	↓	0.22 ± 0.09	0.23 ± 0.06	0.74	↓
Lungs	0.14 ± 0.02	0.17 ± 0.05	0.11	↓	0.11 ± 0.02	0.12 ± 0.02	0.30	↓
Lymph node	1.00 ± 0.17	0.92 ± 0.13	0.30	↑	0.75 ± 0.22	0.95 ± 0.22	0.05	↓
Muscle	0.07 ± 0.01	0.09 ± 0.02	0.01	↓	0.05 ± 0.02	0.07 ± 0.02	0.09	↓
Pancreas	0.26 ± 0.04	0.38 ± 0.09	0.006	↓	0.20 ± 0.06	0.24 ± 0.06	0.26	↓
Plasma	0.05 ± 0.01	0.03 ± 0.02	0.05	↑	0.08 ± 0.03	0.06 ± 0.04	0.17	↑
Salivary gland	ND	ND	ND	ND	0.61 ± 0.33	0.82 ± 0.20	0.11	↓
Skin	0.26 ± 0.10	0.14 ± 0.05	0.02	↑	0.15 ± 0.04	0.17 ± 0.03	0.32	↓
Skull	0.08 ± 0.02	0.09 ± 0.02	0.48	↓	0.06 ± 0.03	0.06 ± 0.02	0.82	↓
Small intestine	0.44 ± 0.09	0.52 ± 0.11	0.1	↓	0.30 ± 0.08	0.37 ± 0.10	0.10	↓
Spleen	0.92 ± 0.32	1.52 ± 0.38	0.004	↓	0.56 ± 0.31	0.91 ± 0.39	0.04	↓
Urine	3.01 ± 2.69	2.35 ± 0.98	0.53	↑	7.22 ± 5.62	9.66 ± 12.70	0.59	↓
White adipose	0.05 ± 0.02	0.07 ± 0.02	0.04	↓	0.031 ± 0.01	0.035 ± 0.01	0.27	↓

Results are means ± SDs
ND not determined

Back to article page

ISSN: 1742-2094

Contact us

Submission enquiries: journalsubmissions@springernature.com