Table 2 Ex vivo biodistribution (organ/blood ratio) of ⁶⁸Ga-FOL at 30 min post-injection in rats with fDTH-EAE after treatment with EC2319 or saline

Adrenal glands

9.55 ± 4.32

17.55 ± 2.91

< 0.001

↓

3.02 ± 1.65

9.89 ± 6.92

0.01

↓

Brain

0.73 ± 0.16

0.80 ± 0.24

0.51

↓

0.48 ± 0.39

0.90 ± 0.58

0.08

↓

Heart

4.94 ± 2.68

13.72 ± 5.17

0.002

↓

1.70 ± 0.81

4.50 ± 3.35

0.03

↓

Kidneys

483.01 ± 135.74

480.04 ± 108.58

0.96

↑

168.51 ± 119.09

371.09 ± 188.35

0.01

↓

Liver

12.03 ± 5.98

34.06 ± 10.74

< 0.001

↓

4.49 ± 3.6

11.82 ± 8.8

0.03

↓

Lungs

5.57 ± 2.54

12.44 ± 3.99

0.0015

↓

2.14 ± 0.99

5.99 ± 4.21

0.02

↓

Lymph node

38.28 ± 13.38

64.84 ± 6.42

< 0.001

↓

14.83 ± 9.51

46.01 ± 30.30

0.01

↓

Muscle

2.82 ± 1.16

6.85 ± 1.97

< 0.001

↓

1.04 ± 0.58

3.47 ± 2.54

0.02

↓

Pancreas

10.19 ± 3.83

27.53 ± 7.49

< 0.001

↓

3.90 ± 2.24

11.94 ± 8.63

0.02

↓

Plasma

1.85 ± 0.78

2.17 ± 1.58

0.62

↓

1.43 ± 0.45

1.71 ± 0.11

0.08

↓

Salivary gland

ND

ND

ND

ND

11.98 ± 9.84

39.39 ± 24.62

0.01

↓

Skin

10.53 ± 8.71

10.30 ± 4.02

0.95

↑

2.47 ± 1.65

7.44 ± 4.34

0.01

↓

Skull

3.23 ± 1.58

6.32 ± 1.63

0.002

↓

1.19 ± 0.98

2.99 ± 2.28

0.04

↓

Small intestine

16.99 ± 7.46

37.82 ± 9.98

< 0.001

↓

5.71 ± 3.10

18.63 ± 14.02

0.02

↓

Spleen

36.02 ± 17.56

107.40 ± 24.24

< 0.001

↓

9.68 ± 3.79

47.82 ± 39.15

0.01

↓

Urine

102.82 ± 67.31

167.88 ± 76.67

0.09

↓

132.55 ± 92.40

218.37 ± 168.11

0.18

↓

White adipose

1.93 ± 0.81

5.07 ± 1.32

< 0.001

↓

0.61 ± 0.36

1.53 ± 0.88

0.01

↓