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Table 2 Ex vivo biodistribution (organ/blood ratio) of 68Ga-FOL at 30 min post-injection in rats with fDTH-EAE after treatment with EC2319 or saline

From: Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis

Organ Day 14 Day 90
EC2319 (n = 8) Saline (n = 8) P value Treatment effect EC2319 (n = 10) Saline (n = 10) P value Treatment effect
Adrenal glands 9.55 ± 4.32 17.55 ± 2.91 < 0.001 3.02 ± 1.65 9.89 ± 6.92 0.01
Brain 0.73 ± 0.16 0.80 ± 0.24 0.51 0.48 ± 0.39 0.90 ± 0.58 0.08
Heart 4.94 ± 2.68 13.72 ± 5.17 0.002 1.70 ± 0.81 4.50 ± 3.35 0.03
Kidneys 483.01 ± 135.74 480.04 ± 108.58 0.96 168.51 ± 119.09 371.09 ± 188.35 0.01
Liver 12.03 ± 5.98 34.06 ± 10.74 < 0.001 4.49 ± 3.6 11.82 ± 8.8 0.03
Lungs 5.57 ± 2.54 12.44 ± 3.99 0.0015 2.14 ± 0.99 5.99 ± 4.21 0.02
Lymph node 38.28 ± 13.38 64.84 ± 6.42 < 0.001 14.83 ± 9.51 46.01 ± 30.30 0.01
Muscle 2.82 ± 1.16 6.85 ± 1.97 < 0.001 1.04 ± 0.58 3.47 ± 2.54 0.02
Pancreas 10.19 ± 3.83 27.53 ± 7.49 < 0.001 3.90 ± 2.24 11.94 ± 8.63 0.02
Plasma 1.85 ± 0.78 2.17 ± 1.58 0.62 1.43 ± 0.45 1.71 ± 0.11 0.08
Salivary gland ND ND ND ND 11.98 ± 9.84 39.39 ± 24.62 0.01
Skin 10.53 ± 8.71 10.30 ± 4.02 0.95 2.47 ± 1.65 7.44 ± 4.34 0.01
Skull 3.23 ± 1.58 6.32 ± 1.63 0.002 1.19 ± 0.98 2.99 ± 2.28 0.04
Small intestine 16.99 ± 7.46 37.82 ± 9.98 < 0.001 5.71 ± 3.10 18.63 ± 14.02 0.02
Spleen 36.02 ± 17.56 107.40 ± 24.24 < 0.001 9.68 ± 3.79 47.82 ± 39.15 0.01
Urine 102.82 ± 67.31 167.88 ± 76.67 0.09 132.55 ± 92.40 218.37 ± 168.11 0.18
White adipose 1.93 ± 0.81 5.07 ± 1.32 < 0.001 0.61 ± 0.36 1.53 ± 0.88 0.01
  1. Results are expressed as mean ± SDs
  2. ND not determined