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Table 3 Ex vivo biodistribution of 68Ga-FOL at 30 min post-injection on day 14 in healthy Lewis rats

From: Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis

Organ %ID/g Organ/blood ratio
EC2319 (n = 10) Saline (n = 10) P value Treatment effect EC2319 (n = 8) Saline (n = 8) P value Treatment effect
Adrenal glands 0.31 ± 0.09 0.35 ± 0.06 0.25 5.92 ± 1.69 10.80 ± 2.19 < 0.001
Blood 0.05 ± 0.02 0.03 ± 0.01 0.004 ND ND ND ND
Brain 0.04 ± 0.01 0.02 ± 0.003 < 0.001 0.73 ± 0.13 0.59 ± 0.09 0.027
Heart 0.18 ± 0.08 0.20 ± 0.03 0.37 3.35 ± 1.51 6.19 ± 0.85 < 0.001
Kidneys 13.18 ± 4.39 6.17 ± 1.13 < 0.001 252.84 ± 84.26 170.46 ± 18.89 0.037
Liver 0.26 ± 0.07 0.47 ± 0.15 0.03 4.89 ± 1.31 14.92 ± 4.85 < 0.001
Lungs 0.16 ± 0.03 0.22 ± 0.03 < 0.001 3.03 ± 0.58 6.94 ± 0.79 < 0.001
Lymph node 0.94 ± 0.25 0.88 ± 0.08 0.52 17.96 ± 4.75 27.35 ± 2.01 < 0.001
Muscle 0.11 ± 0.05 0.09 ± 0.01 0.12 2.15 ± 0.89 2.66 ± 0.28 0.17
Pancreas 0.29 ± 0.06 0.36 ± 0.04 0.16 5.59 ± 1.05 9.96 ± 1.42 < 0.001
Plasma 0.09 ± 0.03 0.06 ± 0.02 0.01 1.73 ± 0.49 1.95 ± 0.61 0.89
Salivary gland 1.01 ± 0.35 1.24 ± 0.21 0.10 19.28 ± 6.74 38.39 ± 6.48 < 0.001
Skin 0.23 ± 0.07 0.21 ± 0.08 0.69 4.33 ± 1.32 5.99 ± 2.08 0.04
Skull 0.07 ± 0.03 0.15 ± 0.04 < 0.001 1.32 ± 0.54 4.81 ± 1.16 < 0.001
Small intestine 0.56 ± 0.15 0.78 ± 0.10 0.002 10.70 ± 2.87 24.30 ± 2.49 < 0.001
Spleen 0.75 ± 0.31 1.83 ± 0.37 < 0.001 14.45 ± 5.88 55.95 ± 11.99 < 0.001
Urine 3.00 ± 2.08 2.86 ± 0.02 0.32 57.62 ± 39.86 92.25 ± 39.95 0.13
White adipose 0.05 ± 0.02 0.03 ± 0.01 0.004 1.04 ± 0.17 1.45 ± 0.55 0.04
  1. Results are expressed as mean ± SDs
  2. ND not determined