Journal of Neuroinflammation

Table 3 Ex vivo biodistribution of ⁶⁸Ga-FOL at 30 min post-injection on day 14 in healthy Lewis rats

From: Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis

Organ	%ID/g				Organ/blood ratio
Organ	EC2319 (n = 10)	Saline (n = 10)	P value	Treatment effect	EC2319 (n = 8)	Saline (n = 8)	P value	Treatment effect
Adrenal glands	0.31 ± 0.09	0.35 ± 0.06	0.25	↓	5.92 ± 1.69	10.80 ± 2.19	< 0.001	↓
Blood	0.05 ± 0.02	0.03 ± 0.01	0.004	↑	ND	ND	ND	ND
Brain	0.04 ± 0.01	0.02 ± 0.003	< 0.001	↑	0.73 ± 0.13	0.59 ± 0.09	0.027	↑
Heart	0.18 ± 0.08	0.20 ± 0.03	0.37	↓	3.35 ± 1.51	6.19 ± 0.85	< 0.001	↓
Kidneys	13.18 ± 4.39	6.17 ± 1.13	< 0.001	↑	252.84 ± 84.26	170.46 ± 18.89	0.037	↑
Liver	0.26 ± 0.07	0.47 ± 0.15	0.03	↓	4.89 ± 1.31	14.92 ± 4.85	< 0.001	↓
Lungs	0.16 ± 0.03	0.22 ± 0.03	< 0.001	↓	3.03 ± 0.58	6.94 ± 0.79	< 0.001	↓
Lymph node	0.94 ± 0.25	0.88 ± 0.08	0.52	↑	17.96 ± 4.75	27.35 ± 2.01	< 0.001	↓
Muscle	0.11 ± 0.05	0.09 ± 0.01	0.12	↑	2.15 ± 0.89	2.66 ± 0.28	0.17	↓
Pancreas	0.29 ± 0.06	0.36 ± 0.04	0.16	↓	5.59 ± 1.05	9.96 ± 1.42	< 0.001	↓
Plasma	0.09 ± 0.03	0.06 ± 0.02	0.01	↑	1.73 ± 0.49	1.95 ± 0.61	0.89	↓
Salivary gland	1.01 ± 0.35	1.24 ± 0.21	0.10	↓	19.28 ± 6.74	38.39 ± 6.48	< 0.001	↓
Skin	0.23 ± 0.07	0.21 ± 0.08	0.69	↑	4.33 ± 1.32	5.99 ± 2.08	0.04	↓
Skull	0.07 ± 0.03	0.15 ± 0.04	< 0.001	↓	1.32 ± 0.54	4.81 ± 1.16	< 0.001	↓
Small intestine	0.56 ± 0.15	0.78 ± 0.10	0.002	↓	10.70 ± 2.87	24.30 ± 2.49	< 0.001	↓
Spleen	0.75 ± 0.31	1.83 ± 0.37	< 0.001	↓	14.45 ± 5.88	55.95 ± 11.99	< 0.001	↓
Urine	3.00 ± 2.08	2.86 ± 0.02	0.32	↑	57.62 ± 39.86	92.25 ± 39.95	0.13	↓
White adipose	0.05 ± 0.02	0.03 ± 0.01	0.004	↑	1.04 ± 0.17	1.45 ± 0.55	0.04	↓

Results are expressed as mean ± SDs
ND not determined

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ISSN: 1742-2094

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