Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis

Table 4 Rat plasma levels of cytokines (pg/mL)

Cytokine	fDTH-EAE day 14			fDTH-EAE day 90			Healthy Lewis rats
Cytokine	EC2319 (n = 2)	Saline (n = 4–6)	P value	EC2319 (n = 2–4)	Saline (n = 5–7)	P value	EC2319 (n = 4–6)	Saline (n = 3–7)	P value
IFN-γ	ND	202 ± 152	0.92	216 ± 184	95 ± 77^b	0.29	486 ± 507	558 ± 755^b	0.81
IL-1β	662 ± 614	441 ± 284	0.53	205 ± 178	203 ± 79^b	0.97	321 ± 167	562 ± 316^b	0.02
IL-4	ND	42 ± 29	0.60	28 ± 17	29 ± 22^b	0.96	70 ± 70	234 ± 237^b	0.09
IL-6	ND	442 ± 266^a	0.74	ND	ND	ND	486 ± 386	5210 ± 4146^a	0.06
IL-10	780 ± 548	604 ± 290	0.58	417 ± 259	395 ± 121^b	0.82	479 ± 194	700 ± 297^b	0.03

ISSN: 1742-2094