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Table 1 Physiological variables at baseline, hypoxia, and the post-hypoxic period in rats receiving intrathecal cervical spinal injections of the vehicle, or okadaic acid

From: Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity

Experimental groups

PaCO2 (mmHg)

PaO2 (mmHg)

SBEc

mmol/L

Sham + vehicle + mAIH

 Baseline

44.0 ± 1.5

315 ± 11

1.13 ± 0.2

 Hypoxia

43.6 ± 1.4

40 ± 1.0*

1.35 ± 0.4

 30 min

43.9 ± 1.7

256 ± 16*

1.20 ± 0.4

 60 min

44.2 ± 1.3

279 ± 2*

1.75 ± 0.5

 90 min

44.5 ± 1.5

265 ± 9*

1.55 ± 0.5

LPS + vehicle + mAIH

 Baseline

42.4 ± 1.2

318 ± 10

0.3 ± 0.6

 Hypoxia

42.3 ± 1.0

42 ± 1.3*

0.8 ± 0.5

 30 min

42.4 ± 1.1

270 ± 18*

2.1 ± 0.7

 60 min

42.2 ± 1.3

276 ± 11*

1.6 ± 0.9

 90 min

42.3 ± 1.2

283 ± 11*

0.9 ± 0.9

Sham + okadaic acid + mAIH

 Baseline

43.8 ± 1.5

313 ± 10

1.3 ± 0.6

 Hypoxia

44.0 ± 1.3

40 ± 2.4*

0.1 ± 0.5

 30 min

43.9 ± 0.8

249 ± 16*

1.6 ± 0.67

 60 min

43.9 ± 1.4

251 ± 22*

0.6 ± 0.4

 90 min

43.8 ± 0.9

240 ± 26*

− 0.4 ± 0.7

LPS + okadaic acid + mAIH

 Baseline

40.5 ± 1.0

317 ± 7.8

0.7 ± 0.6

 Hypoxia

41.2 ± 1.1

40 ± 1.3*

2.0 ± 0.3

 30 min

40.6 ± 1.0

268 ± 14*

2.4 ± 0.3

 60 min

40.6 ± 0.7

268 ± 11*

2.1 ± 0.3

 90 min

41.2 ± 0.8

261 ± 12*

1.6 ± 0.5

  1. Values are means ± SE. Sham refers to group of rats that were injected with saline (i.p.) 24 h before start of experiments. Similarly, in different group of rats, LPS was also given 24 h before experiments began. Vehicle (aCSF) or okadaic acid solution were delivered intrathecally at the cervical spinal cord
  2. PaCO2 arterial CO2 pressure, PaO2 arterial O2 pressure, SBEc standard excess base
  3. *Represents a significant difference compared to baseline (P < 0.05)