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Table 1 Physiological variables at baseline, hypoxia, and the post-hypoxic period in rats receiving intrathecal cervical spinal injections of the vehicle, or okadaic acid

From: Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity

Experimental groups PaCO2 (mmHg) PaO2 (mmHg) SBEc
mmol/L
Sham + vehicle + mAIH
 Baseline 44.0 ± 1.5 315 ± 11 1.13 ± 0.2
 Hypoxia 43.6 ± 1.4 40 ± 1.0* 1.35 ± 0.4
 30 min 43.9 ± 1.7 256 ± 16* 1.20 ± 0.4
 60 min 44.2 ± 1.3 279 ± 2* 1.75 ± 0.5
 90 min 44.5 ± 1.5 265 ± 9* 1.55 ± 0.5
LPS + vehicle + mAIH
 Baseline 42.4 ± 1.2 318 ± 10 0.3 ± 0.6
 Hypoxia 42.3 ± 1.0 42 ± 1.3* 0.8 ± 0.5
 30 min 42.4 ± 1.1 270 ± 18* 2.1 ± 0.7
 60 min 42.2 ± 1.3 276 ± 11* 1.6 ± 0.9
 90 min 42.3 ± 1.2 283 ± 11* 0.9 ± 0.9
Sham + okadaic acid + mAIH
 Baseline 43.8 ± 1.5 313 ± 10 1.3 ± 0.6
 Hypoxia 44.0 ± 1.3 40 ± 2.4* 0.1 ± 0.5
 30 min 43.9 ± 0.8 249 ± 16* 1.6 ± 0.67
 60 min 43.9 ± 1.4 251 ± 22* 0.6 ± 0.4
 90 min 43.8 ± 0.9 240 ± 26* − 0.4 ± 0.7
LPS + okadaic acid + mAIH
 Baseline 40.5 ± 1.0 317 ± 7.8 0.7 ± 0.6
 Hypoxia 41.2 ± 1.1 40 ± 1.3* 2.0 ± 0.3
 30 min 40.6 ± 1.0 268 ± 14* 2.4 ± 0.3
 60 min 40.6 ± 0.7 268 ± 11* 2.1 ± 0.3
 90 min 41.2 ± 0.8 261 ± 12* 1.6 ± 0.5
  1. Values are means ± SE. Sham refers to group of rats that were injected with saline (i.p.) 24 h before start of experiments. Similarly, in different group of rats, LPS was also given 24 h before experiments began. Vehicle (aCSF) or okadaic acid solution were delivered intrathecally at the cervical spinal cord
  2. PaCO2 arterial CO2 pressure, PaO2 arterial O2 pressure, SBEc standard excess base
  3. *Represents a significant difference compared to baseline (P < 0.05)