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Table 2 Physiological variables at baseline and for 90 min post-intrathecal injections of either the vehicle or okadaic acid in time-control recordings

From: Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity

Experimental groups PaCO2 (mmHg) PaO2 (mmHg) SBEc
mmol/L
Sham + vehicle time control
 Baseline 42.5 ± 1.2 304 ± 9 1.4 ± 0.5
 30 min 43.1 ± 1.1 278 ± 13* 2.4 ± 0.5
 60 min 42.4 ± 1.2 288 ± 10* 2.5 ± 0.5
 90 min 42.9 ± 0.9 289 ± 7* 2.6 ± 0.6
LPS + vehicle time control
 Baseline 42.7 ± 0.6 318 ± 7 1.6 ± 0.4
 30 min 43.0 ± 0.5 306 ± 9 1.8 ± 0.5
 60 min 42.1 ± 0.6 303 ± 10 1.3 ± 0.6
 90 min 42.7 ± 0.4 301 ± 8 1.7 ± 0.5
Sham + okadaic acid time control
 Baseline 40.9 ± 0.8 315 ± 5 0.20 ± 0.6
 30 min 41.5 ± 0.6 309 ± 6 1.4 ± 0.5
 60 min 41.2 ± 0.8 304 ± 7 1.0 ± 0.6
 90 min 40.0 ± 0.9 290 ± 10* − 0.4 ± 0.9
LPS+ okadaic acid time control
 Baseline 45.7 ± 2.2 279 ± 11 1.6 ± 0.4
 30 min 45.6 ± 2.4 270 ± 9 1.8 ± 0.5
 60 min 45.6 ± 2.1 258 ± 12 1.3 ± 0.6
 90 min 45.8 ± 2.3 245 ± 20 1.7 ± 0.6
  1. Values are means ± SE. Sham refers to group of rats that were injected with saline (i.p.) 24 h before start of experiments. Similarly, in different group of rats, LPS was also given 24 h before experiments began. Time control recordings are from rats that did not get exposed to intermittent hypoxia
  2. PaCO2 arterial CO2 pressure, PaO2 arterial O2 pressure, SBEc standard excess base
  3. *Represents a significant difference compared to baseline (P < 0.05)