Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity

Table 2 Physiological variables at baseline and for 90 min post-intrathecal injections of either the vehicle or okadaic acid in time-control recordings

Experimental groups	PaCO₂ (mmHg)	PaO₂ (mmHg)	SBEc mmol/L
Sham + vehicle time control
Baseline	42.5 ± 1.2	304 ± 9	1.4 ± 0.5
30 min	43.1 ± 1.1	278 ± 13*	2.4 ± 0.5
60 min	42.4 ± 1.2	288 ± 10*	2.5 ± 0.5
90 min	42.9 ± 0.9	289 ± 7*	2.6 ± 0.6
LPS + vehicle time control
Baseline	42.7 ± 0.6	318 ± 7	1.6 ± 0.4
30 min	43.0 ± 0.5	306 ± 9	1.8 ± 0.5
60 min	42.1 ± 0.6	303 ± 10	1.3 ± 0.6
90 min	42.7 ± 0.4	301 ± 8	1.7 ± 0.5
Sham + okadaic acid time control
Baseline	40.9 ± 0.8	315 ± 5	0.20 ± 0.6
30 min	41.5 ± 0.6	309 ± 6	1.4 ± 0.5
60 min	41.2 ± 0.8	304 ± 7	1.0 ± 0.6
90 min	40.0 ± 0.9	290 ± 10*	− 0.4 ± 0.9
LPS+ okadaic acid time control
Baseline	45.7 ± 2.2	279 ± 11	1.6 ± 0.4
30 min	45.6 ± 2.4	270 ± 9	1.8 ± 0.5
60 min	45.6 ± 2.1	258 ± 12	1.3 ± 0.6
90 min	45.8 ± 2.3	245 ± 20	1.7 ± 0.6

Values are means ± SE. Sham refers to group of rats that were injected with saline (i.p.) 24 h before start of experiments. Similarly, in different group of rats, LPS was also given 24 h before experiments began. Time control recordings are from rats that did not get exposed to intermittent hypoxia
PaCO₂ arterial CO₂ pressure, PaO₂ arterial O₂ pressure, SBEc standard excess base
*Represents a significant difference compared to baseline (P < 0.05)

ISSN: 1742-2094