Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity

Table 3 Arterial pressure and respiratory frequency in sham or LPS-injected rats receiving either spinal intrathecal vehicle or okadaic acid

Experimental groups	Arterial pressure (mmHg)	Respiratory frequency
Sham + vehicle + mAIH
Baseline	127 ± 6	53 ± 2
30 min	105 ± 5*	53 ± 3
60 min	96 ± 7*	54 ± 2
90 min	91 ± 5*	54 ± 2
LPS + vehicle + mAIH
Baseline	131 ± 9	55 ± 3
30 min	113 ± 10*	49 ± 5
60 min	106 ± 11*	50 ± 4
90 min	102 ± 10*	49 ± 4
Sham + okadaic acid + mAIH
Baseline	117 ± 4	52 ± 2
30 min	104 ± 6*	51 ± 1
60 min	97 ± 6*	54 ± 1
90 min	96 ± 7*	54 ± 1
LPS + okadaic acid + mAIH
Baseline	114 ± 10	51 ± 2
30 min	102 ± 7	50 ± 2
60 min	100 ± 5	52 ± 2
90 min	98 ± 5	52 ± 2
Sham + vehicle time control
Baseline	115 ± 6	50 ± 5
30 min	108 ± 10	49 ± 3
60 min	98 ± 9	49 ± 5
90 min	99 ± 11	46 ± 2
LPS + vehicle time control
Baseline	117 ± 12	50 ± 3
30 min	96 ± 12	48 ± 4
60 min	91 ± 13	46 ± 4*
90 min	90 ± 11	46 ± 3*
Sham + okadaic acid time control
Baseline	104 ± 6	49 ± 2
30 min	98 ± 5	50 ± 2
60 min	92 ± 6	49 ± 2
90 min	84 ± 6*	48 ± 3
LPS + okadaic acid time control
Baseline	113 ± 12	48 ± 2
30 min	98 ± 12	49 ± 2
60 min	99 ± 10	48 ± 3
90 min	94 ± 11	48 ± 2

Values are means ± SE. Data represents values at baseline and at 30, 60, and 90 min post hypoxia, or at equivalent time points in time-matched control recordings (i.e., no hypoxia). Sham refers to group of rats that were injected with saline (i.p.) 24 h before start of experiments. Similarly, in different group of rats, LPS was also given 24 h before experiments began
PaCO₂ arterial CO₂ pressure, PaO₂ arterial O₂ pressure, SBEc standard excess base *Represents a significant difference compared to baseline (P < 0.05)

ISSN: 1742-2094