Skip to main content

Table 3 Arterial pressure and respiratory frequency in sham or LPS-injected rats receiving either spinal intrathecal vehicle or okadaic acid

From: Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity

Experimental groups Arterial pressure (mmHg) Respiratory frequency
Sham + vehicle + mAIH
 Baseline 127 ± 6 53 ± 2
 30 min 105 ± 5* 53 ± 3
 60 min 96 ± 7* 54 ± 2
 90 min 91 ± 5* 54 ± 2
LPS + vehicle + mAIH
 Baseline 131 ± 9 55 ± 3
 30 min 113 ± 10* 49 ± 5
 60 min 106 ± 11* 50 ± 4
 90 min 102 ± 10* 49 ± 4
Sham + okadaic acid + mAIH
 Baseline 117 ± 4 52 ± 2
 30 min 104 ± 6* 51 ± 1
 60 min 97 ± 6* 54 ± 1
 90 min 96 ± 7* 54 ± 1
LPS + okadaic acid + mAIH
 Baseline 114 ± 10 51 ± 2
 30 min 102 ± 7 50 ± 2
 60 min 100 ± 5 52 ± 2
 90 min 98 ± 5 52 ± 2
Sham + vehicle time control
 Baseline 115 ± 6 50 ± 5
 30 min 108 ± 10 49 ± 3
 60 min 98 ± 9 49 ± 5
 90 min 99 ± 11 46 ± 2
LPS + vehicle time control
 Baseline 117 ± 12 50 ± 3
 30 min 96 ± 12 48 ± 4
 60 min 91 ± 13 46 ± 4*
 90 min 90 ± 11 46 ± 3*
Sham + okadaic acid time control
 Baseline 104 ± 6 49 ± 2
 30 min 98 ± 5 50 ± 2
 60 min 92 ± 6 49 ± 2
 90 min 84 ± 6* 48 ± 3
LPS + okadaic acid time control
 Baseline 113 ± 12 48 ± 2
 30 min 98 ± 12 49 ± 2
 60 min 99 ± 10 48 ± 3
 90 min 94 ± 11 48 ± 2
  1. Values are means ± SE. Data represents values at baseline and at 30, 60, and 90 min post hypoxia, or at equivalent time points in time-matched control recordings (i.e., no hypoxia). Sham refers to group of rats that were injected with saline (i.p.) 24 h before start of experiments. Similarly, in different group of rats, LPS was also given 24 h before experiments began
  2. PaCO2 arterial CO2 pressure, PaO2 arterial O2 pressure, SBEc standard excess base *Represents a significant difference compared to baseline (P < 0.05)