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Table 3 Arterial pressure and respiratory frequency in sham or LPS-injected rats receiving either spinal intrathecal vehicle or okadaic acid

From: Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity

Experimental groups

Arterial pressure (mmHg)

Respiratory frequency

Sham + vehicle + mAIH

 Baseline

127 ± 6

53 ± 2

 30 min

105 ± 5*

53 ± 3

 60 min

96 ± 7*

54 ± 2

 90 min

91 ± 5*

54 ± 2

LPS + vehicle + mAIH

 Baseline

131 ± 9

55 ± 3

 30 min

113 ± 10*

49 ± 5

 60 min

106 ± 11*

50 ± 4

 90 min

102 ± 10*

49 ± 4

Sham + okadaic acid + mAIH

 Baseline

117 ± 4

52 ± 2

 30 min

104 ± 6*

51 ± 1

 60 min

97 ± 6*

54 ± 1

 90 min

96 ± 7*

54 ± 1

LPS + okadaic acid + mAIH

 Baseline

114 ± 10

51 ± 2

 30 min

102 ± 7

50 ± 2

 60 min

100 ± 5

52 ± 2

 90 min

98 ± 5

52 ± 2

Sham + vehicle time control

 Baseline

115 ± 6

50 ± 5

 30 min

108 ± 10

49 ± 3

 60 min

98 ± 9

49 ± 5

 90 min

99 ± 11

46 ± 2

LPS + vehicle time control

 Baseline

117 ± 12

50 ± 3

 30 min

96 ± 12

48 ± 4

 60 min

91 ± 13

46 ± 4*

 90 min

90 ± 11

46 ± 3*

Sham + okadaic acid time control

 Baseline

104 ± 6

49 ± 2

 30 min

98 ± 5

50 ± 2

 60 min

92 ± 6

49 ± 2

 90 min

84 ± 6*

48 ± 3

LPS + okadaic acid time control

 Baseline

113 ± 12

48 ± 2

 30 min

98 ± 12

49 ± 2

 60 min

99 ± 10

48 ± 3

 90 min

94 ± 11

48 ± 2

  1. Values are means ± SE. Data represents values at baseline and at 30, 60, and 90 min post hypoxia, or at equivalent time points in time-matched control recordings (i.e., no hypoxia). Sham refers to group of rats that were injected with saline (i.p.) 24 h before start of experiments. Similarly, in different group of rats, LPS was also given 24 h before experiments began
  2. PaCO2 arterial CO2 pressure, PaO2 arterial O2 pressure, SBEc standard excess base *Represents a significant difference compared to baseline (P < 0.05)