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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis

Fig. 4

Increased TFH-B-Ab response in Prdm1fl/flFoxP3YFP-Cre EAE mice. a Flow cytometry of each indicated subset in mice at day 20 post-EAE induction, as in Fig. 1a. bd Serum IgG and IgE at day 8 (b) or day 20 (c) or anti-MOG IgG and anti-MOG IgE at day 8 (d). e The relationship of serum IgE titers and EAE scores for mice in c. Each dot represents one mouse. f Immunofluorescence analysis of CD3, B220 (left) or B220, IgE and DAPI (right) in the spinal cords. Magnification, × 100. WT, FoxP3YFP-Cre, KO, Prdm1fl/flFoxP3YFP-Cre. Data represent one of at least three experiments (bd n = 5/group). *P < 0.05 and ****P < 0.0001 (unpaired two-tailed Student’s t test). In e, Spearman’s r, ***P = 0.0010. Bars, mean ± SEM

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