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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis

Fig. 6

Transfer of Blimp1-deficient TFR cells promotes EAE. a Schematic presentation of adoptive transfer assay (left) and EAE scores in recipient mice (right). WT, FoxP3YFP-Cre; KO, Prdm1fl/flFoxP3YFP-Cre. bh Schematic diagram of experiment (b), EAE scores in recipient mice (c); serum IgG and IgE or anti-MOG IgG and anti-MOG IgE at day 20 (d), iNOS expression in brain CD45hiCD11bhi cells (e, f), and GM-CSF, IFNγ, and MHCII expression in brain microglia (CD45medCD11b+) of recipients (g, h). WT, Rosa26ERT2-Cre; del, Prdm1fl/flRosa26ERT2-Cre. Data represent one of two experiments (a n = 5/group; c, f, h n = 3–5/group). d Data are pooled from two independent experiments. *P < 0.05, **P < 0.01, and ***P < 0.001 (a, c, two-way ANOVA post hoc Sidak’s multiple comparisons test; d, f, h, unpaired two-tailed Student’s t test). Bars, mean ± SEM

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